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Interleukin 1 receptor antagonist
・ Interleukin 1 receptor, type I
・ Interleukin 1 receptor, type II
・ Interleukin 10
・ Interleukin 10 receptor, alpha subunit
・ Interleukin 10 receptor, beta subunit
・ Interleukin 11
・ Interleukin 11 receptor alpha subunit
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・ Interleukin 13 receptor, alpha 1
・ Interleukin 15


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Interleukin 1 receptor antagonist : ウィキペディア英語版
Interleukin 1 receptor antagonist

The interleukin-1 receptor antagonist (IL-1RA) is a protein that in humans is encoded by the ''IL1RN'' gene.
IL-1RA was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories. IL-1RA, is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R). IL-1R is the same receptor that binds interleukin 1 (IL-1). Hence IL-1RA prevents IL-1 from sending a signal to that cell.
== Function ==

IL-1RA is a member of the interleukin 1 cytokine family. IL1Ra is secreted by various types of cells including immune cells, epithelial cells, and adipocytes, and is a natural inhibitor of the pro-inflammatory effect of IL1β. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3557 )

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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